Publication: Mother-to-child transmission of GB virus C in a cohort of women coinfected with GB virus C and HIV in Bangkok, Thailand
Issued Date
2009-07-15
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ISSN
00221899
DOI
Other identifier(s)
2-s2.0-67650685309
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.200, No.2 (2009), 227-235
Suggested Citation
W. Bhanich Supapol, R. S. Remis, J. Raboud, M. Millson, J. Tappero, R. Kaul, P. Kulkami, M. S. McConnell, P. A. Mock, J. M. McNicholl, N. Vanprapar, S. Asavapiriyanont, N. Shaffer, S. Butera Mother-to-child transmission of GB virus C in a cohort of women coinfected with GB virus C and HIV in Bangkok, Thailand. Journal of Infectious Diseases. Vol.200, No.2 (2009), 227-235. doi:10.1086/599793 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28005
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Title
Mother-to-child transmission of GB virus C in a cohort of women coinfected with GB virus C and HIV in Bangkok, Thailand
Abstract
Background. GB virus C (GBV-C) is an apathogenic virus that inhibits human immunodeficiency virus (HIV) replication in vitro. Mother-to-child transmission (MTCT) of GBV-C has been observed in multiple small studies. Our study examined the rate and correlates of MTCT of GBV-C in a large cohort of GBV-C-HIV-coinfected pregnant women in Thailand. Methods. Maternal delivery plasma specimens from 245 GBV-C-HIV-infected women and specimens from their infants at 4 or 6 months of age were tested for GBV-C RNA. Associations with MTCT of GBV-C were examined using logistic regression. Results. One hundred one (41%) of 245 infants acquired GBV-C infection. MTCT of GBV-C was independently associated with maternal antiretroviral therapy (adjusted odds ratio [AOR], 5.21 [95% confidence interval )CI(, 2.12-12.81]), infant HIV infection (AOR, 0.05 [95% CI, 0.01-0.26]), maternal GBV-C load (≥8.0 log10copies/ mL: AOR, 86.77 [95% CI, 15.27-481.70]; 7.0-7.9 log10copies/mL: AOR, 45.62 [95% CI, 8.41-247.51]; 5.0-6.9 log10copies/mL: AOR, 9.07 [95% CI, 1.85-44.33]: reference, <5 log10viral copies/mL), and caesarean delivery (AOR, 0.26 [95% CI, 0.12-0.59]). Conclusions. Associations with maternal GBV-C load and mode of delivery suggest transmission during pregnancy and delivery. Despite mode of delivery being a common risk factor for virus transmission, GBV-C and HIV were rarely cotransmitted. The mechanisms by which maternal receipt of antiretroviral therapy might increase MTCT of GBV-C are unknown. © 2009 by the Infectious Diseases Society of America. All rights reserved.