Publication:
Molecular screening of the Hbs Constant Spring (codon 142, TAA>CAA, α2) and Paksé (codon 142, TAA>TAT, α2) mutations in Thailand

Issued Date

2010-12-01

Resource Type

Article

ISSN

1532432X
03630269

DOI

10.3109/03630269.2010.526914

Other identifier(s)

2-s2.0-79952162877

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Hemoglobin. Vol.34, No.6 (2010), 582-586

Suggested Citation

Dalad Pichanun, Thongperm Munkongdee, Sumonmaln Klamchuen, Punnee Butthep, Pranee Winichagoon, Suthat Fucharoen, Saovaros Svasti Molecular screening of the Hbs Constant Spring (codon 142, TAA>CAA, α2) and Paksé (codon 142, TAA>TAT, α2) mutations in Thailand. Hemoglobin. Vol.34, No.6 (2010), 582-586. doi:10.3109/03630269.2010.526914 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28584

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Title

Molecular screening of the Hbs Constant Spring (codon 142, TAA>CAA, α2) and Paksé (codon 142, TAA>TAT, α2) mutations in Thailand

Author(s)

Dalad Pichanun
 Thongperm Munkongdee
 Sumonmaln Klamchuen
 Punnee Butthep
 Pranee Winichagoon
 Suthat Fucharoen
 Saovaros Svasti

Other Contributor(s)

Mahidol University
 Nakhonpathom Hospital

Abstract

Hb Constant Spring [Hb CS, α142(H19)Term] and Hb Paksé [α142(H19)Term] occur from the mutation in the termination codon of the α2-globin gene, TAA>CAA (→Gln) and TAA>TAT (→Tyr), respectively. They are the most common nondeletional α-thalassemia (α-thal) variants causing Hb H disease in Southeast Asia. In this study, 587 cord blood samples were screened for the Hb CS and Hb Paksé mutations by a dot-blot hybridization technique using oligonucleotide probes specific for each mutation. The results showed that the prevalence of Hb CS and Hb Paksé in Central Thailand are 5.80 and 0.51%, respectively, which is in concordance with the results from previous studies. © 2010 Informa Healthcare USA, Inc.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/28584

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Scopus 2006-2010