Publication: Molecular screening of the Hbs Constant Spring (codon 142, TAA>CAA, α2) and Paksé (codon 142, TAA>TAT, α2) mutations in Thailand
| dc.contributor.author | Dalad Pichanun | en_US |
| dc.contributor.author | Thongperm Munkongdee | en_US |
| dc.contributor.author | Sumonmaln Klamchuen | en_US |
| dc.contributor.author | Punnee Butthep | en_US |
| dc.contributor.author | Pranee Winichagoon | en_US |
| dc.contributor.author | Suthat Fucharoen | en_US |
| dc.contributor.author | Saovaros Svasti | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Nakhonpathom Hospital | en_US |
| dc.date.accessioned | 2018-09-24T08:41:02Z | |
| dc.date.available | 2018-09-24T08:41:02Z | |
| dc.date.issued | 2010-12-01 | en_US |
| dc.description.abstract | Hb Constant Spring [Hb CS, α142(H19)Term] and Hb Paksé [α142(H19)Term] occur from the mutation in the termination codon of the α2-globin gene, TAA>CAA (→Gln) and TAA>TAT (→Tyr), respectively. They are the most common nondeletional α-thalassemia (α-thal) variants causing Hb H disease in Southeast Asia. In this study, 587 cord blood samples were screened for the Hb CS and Hb Paksé mutations by a dot-blot hybridization technique using oligonucleotide probes specific for each mutation. The results showed that the prevalence of Hb CS and Hb Paksé in Central Thailand are 5.80 and 0.51%, respectively, which is in concordance with the results from previous studies. © 2010 Informa Healthcare USA, Inc. | en_US |
| dc.identifier.citation | Hemoglobin. Vol.34, No.6 (2010), 582-586 | en_US |
| dc.identifier.doi | 10.3109/03630269.2010.526914 | en_US |
| dc.identifier.issn | 1532432X | en_US |
| dc.identifier.issn | 03630269 | en_US |
| dc.identifier.other | 2-s2.0-79952162877 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/28584 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952162877&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Medicine | en_US |
| dc.title | Molecular screening of the Hbs Constant Spring (codon 142, TAA>CAA, α2) and Paksé (codon 142, TAA>TAT, α2) mutations in Thailand | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952162877&origin=inward | en_US |