Publication: The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells
Issued Date
2004-11-23
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ISSN
03043940
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2-s2.0-7444269097
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuroscience Letters. Vol.371, No.2-3 (2004), 205-208
Suggested Citation
Banthit Chetsawang, Piyarat Govitrapong, Manuchair Ebadi The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells. Neuroscience Letters. Vol.371, No.2-3 (2004), 205-208. doi:10.1016/j.neulet.2004.08.068 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21782
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Title
The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells
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Abstract
Melatonin is synthesized mainly in pineal gland. It has been suggested that melatonin has proven antioxidant effects and protective effects against neuronal cell degeneration. There are several studies indicating that c-Jun-N-terminal kinase pathways might be involved in neuronal cell death. In this study, the effects of melatonin on 6-hydroxydopamine (6-OHDA)-treated cultured SK-N-SH cells were investigated. The results showed that 6-OHDA significantly decreased cell viability as determined by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay, and melatonin was able to reverse the toxic effects of 6-OHDA on cell viability. In addition, induction of c-Jun phosphorylation by 6-OHDA was diminished by melatonin. These results demonstrate some protective properties of melatonin against neuronal cell degeneration and its action on the inhibition of c-Jun-N terminal kinase signaling cascade. © 2004 Elsevier Ireland Ltd. All rights reserved.