Publication: The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells
| dc.contributor.author | Banthit Chetsawang | en_US |
| dc.contributor.author | Piyarat Govitrapong | en_US |
| dc.contributor.author | Manuchair Ebadi | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Univ. N. Dakota Sch. M | en_US |
| dc.date.accessioned | 2018-07-24T03:56:29Z | |
| dc.date.available | 2018-07-24T03:56:29Z | |
| dc.date.issued | 2004-11-23 | en_US |
| dc.description.abstract | Melatonin is synthesized mainly in pineal gland. It has been suggested that melatonin has proven antioxidant effects and protective effects against neuronal cell degeneration. There are several studies indicating that c-Jun-N-terminal kinase pathways might be involved in neuronal cell death. In this study, the effects of melatonin on 6-hydroxydopamine (6-OHDA)-treated cultured SK-N-SH cells were investigated. The results showed that 6-OHDA significantly decreased cell viability as determined by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay, and melatonin was able to reverse the toxic effects of 6-OHDA on cell viability. In addition, induction of c-Jun phosphorylation by 6-OHDA was diminished by melatonin. These results demonstrate some protective properties of melatonin against neuronal cell degeneration and its action on the inhibition of c-Jun-N terminal kinase signaling cascade. © 2004 Elsevier Ireland Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Neuroscience Letters. Vol.371, No.2-3 (2004), 205-208 | en_US |
| dc.identifier.doi | 10.1016/j.neulet.2004.08.068 | en_US |
| dc.identifier.issn | 03043940 | en_US |
| dc.identifier.other | 2-s2.0-7444269097 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21782 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=7444269097&origin=inward | en_US |
| dc.subject | Neuroscience | en_US |
| dc.title | The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=7444269097&origin=inward | en_US |