Publication: Selectivity comparisons of monolithic silica capillary columns modified with poly(octadecyl methacrylate) and octadecyl moieties for halogenated compounds in reversed-phase liquid chromatography
Issued Date
2009-08-01
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ISSN
00219673
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2-s2.0-67649662614
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Chromatography A. Vol.1216, No.31 (2009), 5868-5874
Suggested Citation
Wasura Soonthorntantikul, Natchanun Leepipatpiboon, Tohru Ikegami, Nobuo Tanaka, Thumnoon Nhujak Selectivity comparisons of monolithic silica capillary columns modified with poly(octadecyl methacrylate) and octadecyl moieties for halogenated compounds in reversed-phase liquid chromatography. Journal of Chromatography A. Vol.1216, No.31 (2009), 5868-5874. doi:10.1016/j.chroma.2009.06.030 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27169
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Title
Selectivity comparisons of monolithic silica capillary columns modified with poly(octadecyl methacrylate) and octadecyl moieties for halogenated compounds in reversed-phase liquid chromatography
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Abstract
Stationary phase selectivities for halogenated compounds in reversed-phase HPLC were compared using C18 monolithic silica capillary columns modified with poly(octadecyl methacrylate) (ODM) and octadecyl moieties (ODS). The preferential retention of halogenated benzenes on ODM was observed in methanol/water and acetonitrile/water mobile phases. In selectivity comparison of selected analytes on ODM and ODS, greater selectivities for halogenated compounds were obtained with respect to alkylbenzenes on an ODM column, while similar selectivities were observed with a homologous series of alkylbenzenes on ODM and ODS columns. These data can be explained by greater dispersive interactions by more densely packed octadecyl groups on the ODM polymer coated column together with the contribution of carbonyl groups in ODM side chains. For the positional isomeric separation of dihalogenated benzenes (ortho-, meta-, para-), the ODM column also provided better separation of these isomers for the adjacently eluted isomers that cannot be completely separated on an ODS column in the same mobile phase. These results imply that the ODM column can be used as a better alternative to the ODS column for the separation of other halogenated compounds. © 2009 Elsevier B.V. All rights reserved.