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Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus

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dc.contributor.authorKanae Sakaien_US
dc.contributor.authorHiroshi Kinoshitaen_US
dc.contributor.authorTakuya Nihiraen_US
dc.contributor.otherOsaka Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-13T06:21:25Z
dc.date.available2018-09-13T06:21:25Z
dc.date.issued2009-11-01en_US
dc.description.abstractMonacolin K (MK), which is widely used as an antihypercholesterolemia medicine, is produced as a fungal secondary metabolite through the polyketide pathway. The MK biosynthetic gene cluster proposed for Monascus pilosus BCRC38072 was also identified in M. pilosus NBRC4480. The mokB gene, located at the end of the putative gene cluster and possibly encoding polyketide synthase, was disrupted. The mokB disruptant did not produce MK, but accumulated an intermediate that was confirmed to be monacolin J, indicating that mokB encodes the polyketide synthase responsible for the biosynthesis of side-chain diketide moiety. © Springer Science+Business Media B.V. 2009.en_US
dc.identifier.citationBiotechnology Letters. Vol.31, No.12 (2009), 1911-1916en_US
dc.identifier.doi10.1007/s10529-009-0093-3en_US
dc.identifier.issn15736776en_US
dc.identifier.issn01415492en_US
dc.identifier.other2-s2.0-73949088012en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/27122
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73949088012&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleIdentification of mokB involved in monacolin K biosynthesis in Monascus pilosusen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73949088012&origin=inwarden_US

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