Publication:
Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cells

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dc.contributor.authorMasahiro Iwataen_US
dc.contributor.authorKo ichi Kawaharaen_US
dc.contributor.authorHisashi Kawabataen_US
dc.contributor.authorTakashi Itoen_US
dc.contributor.authorKentaro Meraen_US
dc.contributor.authorKamal Krishna Biswasen_US
dc.contributor.authorSalunya Tancharoenen_US
dc.contributor.authorYuko Higashien_US
dc.contributor.authorKiyoshi Kikuchien_US
dc.contributor.authorTeruto Hashiguchien_US
dc.contributor.authorTakuro Kanekuraen_US
dc.contributor.authorIkuro Maruyamaen_US
dc.contributor.otherKagoshima University Faculty of Medicineen_US
dc.contributor.otherDivision of Laboratory and Vascular Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-12T02:15:59Z
dc.date.available2018-07-12T02:15:59Z
dc.date.issued2008-12-12en_US
dc.description.abstractThrombomodulin (TM) is an endothelial cell surface anticoagulant glycoprotein that performs antimetastatic, angiogenic, adhesive, and anti-inflammatory functions in various tissues. It is also expressed in epidermal keratinocytes. We found that a physiological dose (10 mJ/cm2) of mid-wavelength ultraviolet irradiation (UVB) significantly induced TM expression via the p38mitogen-activated protein kinase (MAPK)/cyclic AMP response element (CRE) signaling pathway in the epidermal keratinocyte cell line HaCaT; this shows that TM regulates the survival of HaCaT cells. SB203580, a p38MAPK inhibitor, significantly decreased TM expression and the viability of cells exposed to UVB. Furthermore, overexpression of TM markedly increased cell viability, and it was abrogated by TM small interfering RNA (siRNA), suggesting that TM may play an important role in exerting cytoprotective effect on epidermal keratinocytes against low-dose UVB. © 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationBiochemical and Biophysical Research Communications. Vol.377, No.2 (2008), 642-647en_US
dc.identifier.doi10.1016/j.bbrc.2008.10.049en_US
dc.identifier.issn10902104en_US
dc.identifier.issn0006291Xen_US
dc.identifier.other2-s2.0-55549140799en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/18799
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55549140799&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleThrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cellsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55549140799&origin=inwarden_US

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