Publication: Aqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activity
Issued Date
2020-01-01
Resource Type
ISSN
15403580
10496475
10496475
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2-s2.0-85083635904
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Herbs, Spices and Medicinal Plants. (2020)
Suggested Citation
Sathit Panvilai, Chanita Napaswad, Jitra Limthongkul, Radeekorn Akkarawongsapat Aqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activity. Journal of Herbs, Spices and Medicinal Plants. (2020). doi:10.1080/10496475.2020.1753276 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/54654
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Title
Aqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activity
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Abstract
© 2020, © 2020 Taylor & Francis Group, LLC. Aqueous extracts of selected Thai medicinal plants were assessed for anti-HIV-1 activities in syncytium reduction assay using ∆tat/revMC99/1A2 system and reverse transcription (RT) inhibition assay. Results showed that all the plant extracts inhibited viral syncytium formation with the effective concentrations at 50% (EC50) ranging from 33.9 to 112 µg mL−1. The EC50 values indicated that the extracts were not toxic to 1A2 cells. The selectivity index (SI) ranged from 2.0 to > 6.6. The antiviral activity found in each plant was not due to the inhibition of viral reverse transcriptase enzyme.