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Aqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activity

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dc.contributor.authorSathit Panvilaien_US
dc.contributor.authorChanita Napaswaden_US
dc.contributor.authorJitra Limthongkulen_US
dc.contributor.authorRadeekorn Akkarawongsapaten_US
dc.contributor.otherBansomdejchaopraya Rajabhat Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2020-05-05T05:51:02Z
dc.date.available2020-05-05T05:51:02Z
dc.date.issued2020-01-01en_US
dc.description.abstract© 2020, © 2020 Taylor & Francis Group, LLC. Aqueous extracts of selected Thai medicinal plants were assessed for anti-HIV-1 activities in syncytium reduction assay using ∆tat/revMC99/1A2 system and reverse transcription (RT) inhibition assay. Results showed that all the plant extracts inhibited viral syncytium formation with the effective concentrations at 50% (EC50) ranging from 33.9 to 112 µg mL−1. The EC50 values indicated that the extracts were not toxic to 1A2 cells. The selectivity index (SI) ranged from 2.0 to > 6.6. The antiviral activity found in each plant was not due to the inhibition of viral reverse transcriptase enzyme.en_US
dc.identifier.citationJournal of Herbs, Spices and Medicinal Plants. (2020)en_US
dc.identifier.doi10.1080/10496475.2020.1753276en_US
dc.identifier.issn15403580en_US
dc.identifier.issn10496475en_US
dc.identifier.other2-s2.0-85083635904en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/54654
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083635904&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleAqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activityen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083635904&origin=inwarden_US

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