Publication: Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975
Issued Date
2006-10-01
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ISSN
01633864
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2-s2.0-33845460633
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.69, No.10 (2006), 1404-1410
Suggested Citation
Maneekarn Chinworrungsee, Prasat Kittakoop, Janya Saenboonrueng, Palangpon Kongsaeree, Yodhathai Thebtaranonth Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975. Journal of Natural Products. Vol.69, No.10 (2006), 1404-1410. doi:10.1021/np0601197 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22860
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Title
Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975
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Abstract
Eight new compounds (2-9), together with a known dithiodiketopiperazine (1), were isolated from the seed fungus Menisporopsis theobromae BCC 3975. The structures of these substances were elucidated by analyses of spectroscopic data. Compounds 1 and 4 exhibited moderate cytotoxicity against BC-1 cell lines with IC50 values of 29.2 and 57.4 μM, respectively. Cytotoxicity of 1, 2, 4, and 9 against the NCI-H187 cell line showed respective IC 50 values of 22.9, 20.3, 1.8, and 56.6 μM. Compounds 2 and 4 exhibited antimalarial activity with IC50 values of 2.95 and 28.8 μM, respectively. Substances 1, 4, 7, 8, and 9 possessed weak antimycobacterial activity (MIC 154.8-952.3 μM), while compounds 2 and 3 showed potent antimycobacterial activity with respective MIC values of 1.24 and 7.14 μM. © 2006 American Chemical Society and American Society of Pharmacognosy.