Publication: Non-adherence in non-inferiority trials: Pitfalls and recommendations
Issued Date
2020-07-01
Resource Type
ISSN
17561833
09598146
09598146
Other identifier(s)
2-s2.0-85087472907
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Mahidol University
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SCOPUS
Bibliographic Citation
The BMJ. Vol.370, (2020)
Suggested Citation
Yin Mo, Cherry Lim, James A. Watson, Nicholas J. White, Ben S. Cooper Non-adherence in non-inferiority trials: Pitfalls and recommendations. The BMJ. Vol.370, (2020). doi:10.1136/bmj.m2215 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/58100
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Title
Non-adherence in non-inferiority trials: Pitfalls and recommendations
Abstract
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ. Non-adherence in non-inferiority trials can affect treatment effect estimates and often increases the chance of claiming non-inferiority under the standard intention-to-treat analysis. This article discusses the implications of different patterns of non-adherence in non-inferiority trials and offers practical recommendations for trial design, alternative analysis strategies, and outcome reporting to reduce bias in treatment estimates and improve transparency in reporting.