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Non-adherence in non-inferiority trials: Pitfalls and recommendations

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dc.contributor.authorYin Moen_US
dc.contributor.authorCherry Limen_US
dc.contributor.authorJames A. Watsonen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorBen S. Cooperen_US
dc.contributor.otherNational University Hospital, Singaporeen_US
dc.contributor.otherNational University of Singaporeen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Medicineen_US
dc.date.accessioned2020-08-25T10:32:35Z
dc.date.available2020-08-25T10:32:35Z
dc.date.issued2020-07-01en_US
dc.description.abstract© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ. Non-adherence in non-inferiority trials can affect treatment effect estimates and often increases the chance of claiming non-inferiority under the standard intention-to-treat analysis. This article discusses the implications of different patterns of non-adherence in non-inferiority trials and offers practical recommendations for trial design, alternative analysis strategies, and outcome reporting to reduce bias in treatment estimates and improve transparency in reporting.en_US
dc.identifier.citationThe BMJ. Vol.370, (2020)en_US
dc.identifier.doi10.1136/bmj.m2215en_US
dc.identifier.issn17561833en_US
dc.identifier.issn09598146en_US
dc.identifier.other2-s2.0-85087472907en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/58100
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087472907&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleNon-adherence in non-inferiority trials: Pitfalls and recommendationsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087472907&origin=inwarden_US

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