Publication:
Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice

Issued Date

2005-09-01

Resource Type

Article

ISSN

0367326X

DOI

10.1016/j.fitote.2005.04.015

Other identifier(s)

2-s2.0-26944494633

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Fitoterapia. Vol.76, No.6 (2005), 534-539

Suggested Citation

Ekkasit Kumarnsit, Niwat Keawpradub, Uraporn Vongvatcharanon, Kitja Sawangjaroen, Piyarat Govitrapong Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice. Fitoterapia. Vol.76, No.6 (2005), 534-539. doi:10.1016/j.fitote.2005.04.015 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17160

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice

Author(s)

Ekkasit Kumarnsit
 Niwat Keawpradub
 Uraporn Vongvatcharanon
 Kitja Sawangjaroen
 Piyarat Govitrapong

Other Contributor(s)

Prince of Songkla University
 The Institute of Science and Technology for Research and Development, Mahidol University

Abstract

In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period. © 2005 Elsevier B.V. All rights reserved.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/17160

Collections

Scopus 2001-2005