Publication: Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease
Issued Date
1982-01-01
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ISSN
00015792
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2-s2.0-0020454895
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Mahidol University
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SCOPUS
Bibliographic Citation
Acta Haematologica. Vol.68, No.4 (1982), 317-320
Suggested Citation
S. Vatanavicharn, P. Pringsulka, S. Kritalugsana, P. Phuapairoj, P. Wasi Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease. Acta Haematologica. Vol.68, No.4 (1982), 317-320. doi:10.1159/000207000 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30392
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Title
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease
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Abstract
The plasma zinc and copper and urinary zinc levels were determined by an atomic absorption spectrophotometer technic in 14 patients with hemoglobin (Hb) H disease, 34 patients with β-thalassemia/Hb E disease and 30 control subjects. Plasma zinc levels were lower and the plasma copper levels were higher in the patients than in controls. The plasma Cu:Zn ratios, a more valuable indicator of body zinc status, increased in the diseased subjects, indicating zinc deficiency. Higher urinary zinc levels in the both Hb H disease and β-thalassemia/Hb E disease suggest that chronic hemolysis is responsible for hyperzincuria leading to zinc deficiency. The thalassemic patients with undergrowth had higher plasma Cu:Zn ratios than the patients with normal development, indicating a more severe zinc deficiency in the former.