Publication:
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease

dc.contributor.authorS. Vatanavicharnen_US
dc.contributor.authorP. Pringsulkaen_US
dc.contributor.authorS. Kritalugsanaen_US
dc.contributor.authorP. Phuapairojen_US
dc.contributor.authorP. Wasien_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-12T07:28:09Z
dc.date.available2018-10-12T07:28:09Z
dc.date.issued1982-01-01en_US
dc.description.abstractThe plasma zinc and copper and urinary zinc levels were determined by an atomic absorption spectrophotometer technic in 14 patients with hemoglobin (Hb) H disease, 34 patients with β-thalassemia/Hb E disease and 30 control subjects. Plasma zinc levels were lower and the plasma copper levels were higher in the patients than in controls. The plasma Cu:Zn ratios, a more valuable indicator of body zinc status, increased in the diseased subjects, indicating zinc deficiency. Higher urinary zinc levels in the both Hb H disease and β-thalassemia/Hb E disease suggest that chronic hemolysis is responsible for hyperzincuria leading to zinc deficiency. The thalassemic patients with undergrowth had higher plasma Cu:Zn ratios than the patients with normal development, indicating a more severe zinc deficiency in the former.en_US
dc.identifier.citationActa Haematologica. Vol.68, No.4 (1982), 317-320en_US
dc.identifier.doi10.1159/000207000en_US
dc.identifier.issn00015792en_US
dc.identifier.other2-s2.0-0020454895en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/30392
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020454895&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleZinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E diseaseen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020454895&origin=inwarden_US

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