Publication: Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease
dc.contributor.author | S. Vatanavicharn | en_US |
dc.contributor.author | P. Pringsulka | en_US |
dc.contributor.author | S. Kritalugsana | en_US |
dc.contributor.author | P. Phuapairoj | en_US |
dc.contributor.author | P. Wasi | en_US |
dc.contributor.other | Mahidol University | en_US |
dc.date.accessioned | 2018-10-12T07:28:09Z | |
dc.date.available | 2018-10-12T07:28:09Z | |
dc.date.issued | 1982-01-01 | en_US |
dc.description.abstract | The plasma zinc and copper and urinary zinc levels were determined by an atomic absorption spectrophotometer technic in 14 patients with hemoglobin (Hb) H disease, 34 patients with β-thalassemia/Hb E disease and 30 control subjects. Plasma zinc levels were lower and the plasma copper levels were higher in the patients than in controls. The plasma Cu:Zn ratios, a more valuable indicator of body zinc status, increased in the diseased subjects, indicating zinc deficiency. Higher urinary zinc levels in the both Hb H disease and β-thalassemia/Hb E disease suggest that chronic hemolysis is responsible for hyperzincuria leading to zinc deficiency. The thalassemic patients with undergrowth had higher plasma Cu:Zn ratios than the patients with normal development, indicating a more severe zinc deficiency in the former. | en_US |
dc.identifier.citation | Acta Haematologica. Vol.68, No.4 (1982), 317-320 | en_US |
dc.identifier.doi | 10.1159/000207000 | en_US |
dc.identifier.issn | 00015792 | en_US |
dc.identifier.other | 2-s2.0-0020454895 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/30392 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020454895&origin=inward | en_US |
dc.subject | Medicine | en_US |
dc.title | Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020454895&origin=inward | en_US |