Publication: In vitro delivery of curcumin with cholesterol-based cationic liposomes
Issued Date
2013-07-01
Resource Type
ISSN
10681620
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2-s2.0-84880843147
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Mahidol University
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SCOPUS
Bibliographic Citation
Russian Journal of Bioorganic Chemistry. Vol.39, No.4 (2013), 444-450
Suggested Citation
N. Apiratikul, T. Penglong, K. Suksen, S. Svasti, A. Chairoungdua, B. Yingyongnarongkul In vitro delivery of curcumin with cholesterol-based cationic liposomes. Russian Journal of Bioorganic Chemistry. Vol.39, No.4 (2013), 444-450. doi:10.1134/S1068162013030035 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31282
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Title
In vitro delivery of curcumin with cholesterol-based cationic liposomes
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Abstract
A new cholesterol-based cationic lipid was synthesized; liposomes prepared on its basis were evaluated as drug delivery vehicles for curcumin. Free and liposome-encapsulated curcumin cytotoxicity against HeLa, A549, HepG2, K562 and 1301 cell lines was assessed. Liposomal curcumin with ED50values ranging from 2.5-10 μM exhibited 2-8 times higher cytotoxicity than free curcumin. The synthetic cholesterol-based cationic lipid also enhanced cellular uptake of curcumin into tested cells. Cationic liposome alone showed low cytotoxicity at high doses with ED50values of 90-210 μM. © 2013 Pleiades Publishing, Ltd.