Publication:
In vitro delivery of curcumin with cholesterol-based cationic liposomes

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dc.contributor.authorN. Apiratikulen_US
dc.contributor.authorT. Penglongen_US
dc.contributor.authorK. Suksenen_US
dc.contributor.authorS. Svastien_US
dc.contributor.authorA. Chairoungduaen_US
dc.contributor.authorB. Yingyongnarongkulen_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-19T04:38:20Z
dc.date.available2018-10-19T04:38:20Z
dc.date.issued2013-07-01en_US
dc.description.abstractA new cholesterol-based cationic lipid was synthesized; liposomes prepared on its basis were evaluated as drug delivery vehicles for curcumin. Free and liposome-encapsulated curcumin cytotoxicity against HeLa, A549, HepG2, K562 and 1301 cell lines was assessed. Liposomal curcumin with ED50values ranging from 2.5-10 μM exhibited 2-8 times higher cytotoxicity than free curcumin. The synthetic cholesterol-based cationic lipid also enhanced cellular uptake of curcumin into tested cells. Cationic liposome alone showed low cytotoxicity at high doses with ED50values of 90-210 μM. © 2013 Pleiades Publishing, Ltd.en_US
dc.identifier.citationRussian Journal of Bioorganic Chemistry. Vol.39, No.4 (2013), 444-450en_US
dc.identifier.doi10.1134/S1068162013030035en_US
dc.identifier.issn10681620en_US
dc.identifier.other2-s2.0-84880843147en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/31282
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880843147&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.titleIn vitro delivery of curcumin with cholesterol-based cationic liposomesen_US
dc.typeConference Paperen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880843147&origin=inwarden_US

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