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The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum

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dc.contributor.authorS. Kaewpongsrien_US
dc.contributor.authorK. Sriprawaten_US
dc.contributor.authorR. Suwanarusken_US
dc.contributor.authorD. E. Kyleen_US
dc.contributor.authorU. Lek-Uthaien_US
dc.contributor.authorM. Leimanisen_US
dc.contributor.authorK. M. Lwinen_US
dc.contributor.authorA. P. Phyoen_US
dc.contributor.authorJ. Zwangen_US
dc.contributor.authorB. Russellen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.authorL. Reniaen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherAgency for Science, Technology and Research, Singaporeen_US
dc.contributor.otherUniversity of South Florida Tampaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.date.accessioned2018-05-03T08:35:22Z
dc.date.available2018-05-03T08:35:22Z
dc.date.issued2011-03-01en_US
dc.description.abstractPlasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC 50 ) of P. vivax and P. falciparum to artesunate and chloroquine relative to results with the paired leukocyte-free treatment. Although leukocyte removal is not an essential requirement for the conduct of ex vivo assays, its use has important implications for the interpretation of temporal and spatial antimalarial sensitivity data. Copyright © 2011, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.55, No.3 (2011), 1300-1304en_US
dc.identifier.doi10.1128/AAC.01103-10en_US
dc.identifier.issn10986596en_US
dc.identifier.issn00664804en_US
dc.identifier.other2-s2.0-79952347602en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/12627
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952347602&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleThe presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparumen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952347602&origin=inwarden_US

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