Publication:
Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin

Issued Date

1980-01-01

Resource Type

Article

ISSN

00092797

DOI

10.1016/0009-2797(80)90045-9

Other identifier(s)

2-s2.0-0019160740

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Chemico-Biological Interactions. Vol.33, No.1 (1980), 83-90

Suggested Citation

Amornrat Jearnpipatkul, Bhinyo Panijpan Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin. Chemico-Biological Interactions. Vol.33, No.1 (1980), 83-90. doi:10.1016/0009-2797(80)90045-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11190

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Title

Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin

Author(s)

Amornrat Jearnpipatkul
 Bhinyo Panijpan

Other Contributor(s)

Mahidol University

Abstract

Chloroquine, quinine, mefloquine and quinacrine have been found by difference spectroscopy to interact with hemozoin from Plasmodium berghei, trypsin and pronase-digested methemoglobin, hemin, heme, protoporphyrin IX and hematoporphyrin. These drugs also compete with one another in their binding to hemin. It is proposed that the iron-porphyrin moiety of digested hemoglobin is a common binding site for the accumulation of the schizontocidal drugs in the autophagosomes of the malarial parasite. © 1980.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/11190

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Scopus 1969-1990