Publication: Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin
| dc.contributor.author | Amornrat Jearnpipatkul | en_US |
| dc.contributor.author | Bhinyo Panijpan | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-04-30T08:38:18Z | |
| dc.date.available | 2018-04-30T08:38:18Z | |
| dc.date.issued | 1980-01-01 | en_US |
| dc.description.abstract | Chloroquine, quinine, mefloquine and quinacrine have been found by difference spectroscopy to interact with hemozoin from Plasmodium berghei, trypsin and pronase-digested methemoglobin, hemin, heme, protoporphyrin IX and hematoporphyrin. These drugs also compete with one another in their binding to hemin. It is proposed that the iron-porphyrin moiety of digested hemoglobin is a common binding site for the accumulation of the schizontocidal drugs in the autophagosomes of the malarial parasite. © 1980. | en_US |
| dc.identifier.citation | Chemico-Biological Interactions. Vol.33, No.1 (1980), 83-90 | en_US |
| dc.identifier.doi | 10.1016/0009-2797(80)90045-9 | en_US |
| dc.identifier.issn | 00092797 | en_US |
| dc.identifier.other | 2-s2.0-0019160740 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/11190 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0019160740&origin=inward | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0019160740&origin=inward | en_US |