Publication:
Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part I. Ionisation characteristics of the ligands and their relevance to biological properties

Issued Date

1990-04-17

Resource Type

Article

ISSN

00201693

Other identifier(s)

2-s2.0-0000166947

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Inorganica Chimica Acta. Vol.170, No.2 (1990), 165-170

Suggested Citation

Des R. Richardson, Lucia M. Wis Vitolo, Glenn T. Hefter, Peter M. May, Brian W. Clare, John Webb, P. Wilairat Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part I. Ionisation characteristics of the ligands and their relevance to biological properties. Inorganica Chimica Acta. Vol.170, No.2 (1990), 165-170. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15936

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Title

Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part I. Ionisation characteristics of the ligands and their relevance to biological properties

Author(s)

Des R. Richardson
 Lucia M. Wis Vitolo
 Glenn T. Hefter
 Peter M. May
 Brian W. Clare
 John Webb
 P. Wilairat

Other Contributor(s)

Murdoch University
 Mahidol University

Abstract

The orally effective iron chelator, pyridoxal isonicotinoyl hydrazone (PIH), and five analogues, pyridoxal benzoyl hydrazone (PBH), pyridoxal p-methoxybenzoyl hydrazone ((PpMBH), pyridoxal m-fluorobenzoyl hydrazone (PmFBH), 3-hydroxy- isonicotinaldehyde isonicotinoyl hydrazone (IIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) were synthesised and characterised and their acid dissociation constants measured by glass electrode potentiometry and UV-Vis spectrophotometry. Analysis of the data showed that at physiological pH all of the ligands are predominantly (av. 80%) in the form of the neutral molecule, allowing passage through cell membranes and access to intracellular iron pools. The results are discussed in the context of the development of an orally effective iron chelator for clinical use. © 1990.

Keyword(s)

Chemistry
 Materials Science

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/15936

Collections

Scopus 1969-1990