Publication:
Identification of a novel HIV type 1 CRF01_AE cytotoxic T lymphocyte (CTL) epitope restricted by an HLA-Cw0602 allele and a novel HLA-A0206/peptide restriction

Issued Date

2006-12-01

Resource Type

Article

ISSN

08892229

DOI

10.1089/aid.2006.22.1271

Other identifier(s)

2-s2.0-33846191162

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

AIDS Research and Human Retroviruses. Vol.22, No.12 (2006), 1271-1282

Suggested Citation

Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, Ruengpung Sutthent Identification of a novel HIV type 1 CRF01_AE cytotoxic T lymphocyte (CTL) epitope restricted by an HLA-Cw0602 allele and a novel HLA-A0206/peptide restriction. AIDS Research and Human Retroviruses. Vol.22, No.12 (2006), 1271-1282. doi:10.1089/aid.2006.22.1271 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23278

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Identification of a novel HIV type 1 CRF01_AE cytotoxic T lymphocyte (CTL) epitope restricted by an HLA-Cw0602 allele and a novel HLA-A0206/peptide restriction

Author(s)

Wannee Kantakamalakul
 Mark De Souza
 Sasitorn Bejrachandra
 Silawun Ampol
 Josephine Cox
 Ruengpung Sutthent

Other Contributor(s)

Mahidol University
 Armed Forces Research Institute of Medical Sciences, Thailand
 U.S. Military HIV Research Program

Abstract

This report describes specific T cell responses to HIV-1 CRF01_AE Env and A Gag peptides in 20 HIV-1 CRF01_AE-infected Thai individuals using an interferon-γ (IFN-γ) enzyme-linked immunospot (ELISpot) assay. Twenty-six potentially novel HLA class I-restricted CD8+ T cell epitopes were identified in 14/20 subjects. Fine mapping analysis using the chromium release cytotoxic T lymphocyte (CTL) assay revealed a novel HLA-Cw0602 restricted epitope of HIV-1 CRF01_AE Env (NAKTIIVHL) and a previously identified HIV-1 A Gag epitope (ATLEEMMTA) with a novel HLA-A0206 restriction. © Mary Ann Liebert, Inc.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/23278

Collections

Scopus 2006-2010