Publication:
Misclassification of drug failure in plasmodium falciparum clinical trials in southeast asia

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dc.contributor.authorJonathan J. Julianoen_US
dc.contributor.authorFrederic Arieyen_US
dc.contributor.authorRithy Semen_US
dc.contributor.authorNoppadon Tangpukdeeen_US
dc.contributor.authorSrivicha Krudsooden_US
dc.contributor.authorCarol Olsonen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorWilliam O. Rogersen_US
dc.contributor.authorChansuda Wongsrichanalaien_US
dc.contributor.authorSteven R. Meshnicken_US
dc.contributor.otherSchool of Medicineen_US
dc.contributor.otherThe University of North Carolina at Chapel Hillen_US
dc.contributor.otherLmmtech Pharmaceuticalsen_US
dc.contributor.otherInstitut Pasteur du Cambodgeen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNaval Medical Research Unit Noen_US
dc.date.accessioned2018-09-13T06:56:29Z
dc.date.available2018-09-13T06:56:29Z
dc.date.issued2009-08-15en_US
dc.description.abstractMost trials of antimalarials occur in areas in which reinfections are possible. For Plasmodium falciparum, reinfections are distinguished from recrudescences by polymerase chain reaction analysis of 3 polymorphic genes. However, the validity of this approach has never been rigorously tested. We tested for misclassification in 6 patients from clinical trials in Thailand and Cambodia who were classified as being reinfected by the standard polymerase chain reaction protocol. Using heteroduplex tracking assays and direct DNA sequencing, we found that 5 (83%) of 6 patients were misclassified. Misclassification in this manner overestimates the efficacy of antimalarials and delays the recognition of decreasing therapeutic efficacy, thus delaying potential changes in policy. © 2009 by the Infectious Diseases Society of America. All rights reserved.en_US
dc.identifier.citationJournal of Infectious Diseases. Vol.200, No.4 (2009), 624-628en_US
dc.identifier.doi10.1086/600892en_US
dc.identifier.issn00221899en_US
dc.identifier.other2-s2.0-69149107186en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/27981
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=69149107186&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleMisclassification of drug failure in plasmodium falciparum clinical trials in southeast asiaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=69149107186&origin=inwarden_US

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