Publication: IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
Issued Date
2021-06-01
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23288957
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2-s2.0-85118669660
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Mahidol University
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SCOPUS
Bibliographic Citation
Open Forum Infectious Diseases. Vol.8, No.6 (2021)
Suggested Citation
Rhea J. Longley, Michael T. White, Jessica Brewster, Zoe S.J. Liu, Caitlin Bourke, Eizo Takashima, Matthias Harbers, Wai Hong Tham, Julie Healer, Chetan E. Chitnis, Wuelton Monteiro, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection. Open Forum Infectious Diseases. Vol.8, No.6 (2021). doi:10.1093/ofid/ofab228 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78128
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Title
IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
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Abstract
To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.