Publication: Enhanced dissolution of ursodeoxycholic acid from the solid dispersion
5
Issued Date
1997-01-01
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0030659145
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.23, No.11 (1997), 1115-1121
Suggested Citation
Siriporn Okonogi, Etsuo Yonemochi, Toshio Oguchi, Satit Puttipipatkhachorn, Keiji Yamamoto Enhanced dissolution of ursodeoxycholic acid from the solid dispersion. Drug Development and Industrial Pharmacy. Vol.23, No.11 (1997), 1115-1121. doi:10.3109/03639049709150502 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17939
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Title
Enhanced dissolution of ursodeoxycholic acid from the solid dispersion
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Abstract
Solid dispersions of a very slightly water-soluble drug, ursodeoxycholic acid (UDCA), were prepared using urea, mannitol, and PEG 6000 as a carrier, and the solubility of UDCA was determined in water-ethanol (I:I) mixed solvent as a function of UDCA-carrier ratio. The solubility of UDCA was slightly improved when urea or PEG 6000 was used as a carrier. The powder x-ray diffraction measurements revealed that UDCA did not exist in the crystalline state in the solid dispersions. Differential scanning calorimetry (DSC) studies showed that UDCA was able to dissolve in the melt of urea, mannitol, and PEG 6000. The effect of carriers of solid dispersions on the UDCA dissolution rate was examined. The dissolution rate of UDCA was markedly increased from the solid dispersions of urea, PEG 6000, and mannitol, respectively.