Publication: Enhanced dissolution of ursodeoxycholic acid from the solid dispersion
| dc.contributor.author | Siriporn Okonogi | en_US |
| dc.contributor.author | Etsuo Yonemochi | en_US |
| dc.contributor.author | Toshio Oguchi | en_US |
| dc.contributor.author | Satit Puttipipatkhachorn | en_US |
| dc.contributor.author | Keiji Yamamoto | en_US |
| dc.contributor.other | Chiang Mai University | en_US |
| dc.contributor.other | Chiba University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-07-04T07:42:22Z | |
| dc.date.available | 2018-07-04T07:42:22Z | |
| dc.date.issued | 1997-01-01 | en_US |
| dc.description.abstract | Solid dispersions of a very slightly water-soluble drug, ursodeoxycholic acid (UDCA), were prepared using urea, mannitol, and PEG 6000 as a carrier, and the solubility of UDCA was determined in water-ethanol (I:I) mixed solvent as a function of UDCA-carrier ratio. The solubility of UDCA was slightly improved when urea or PEG 6000 was used as a carrier. The powder x-ray diffraction measurements revealed that UDCA did not exist in the crystalline state in the solid dispersions. Differential scanning calorimetry (DSC) studies showed that UDCA was able to dissolve in the melt of urea, mannitol, and PEG 6000. The effect of carriers of solid dispersions on the UDCA dissolution rate was examined. The dissolution rate of UDCA was markedly increased from the solid dispersions of urea, PEG 6000, and mannitol, respectively. | en_US |
| dc.identifier.citation | Drug Development and Industrial Pharmacy. Vol.23, No.11 (1997), 1115-1121 | en_US |
| dc.identifier.doi | 10.3109/03639049709150502 | en_US |
| dc.identifier.issn | 03639045 | en_US |
| dc.identifier.other | 2-s2.0-0030659145 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/17939 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030659145&origin=inward | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Enhanced dissolution of ursodeoxycholic acid from the solid dispersion | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030659145&origin=inward | en_US |