Publication: Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
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Issued Date
2020-02-28
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-85079751529
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.83, No.2 (2020), 532-536
Suggested Citation
Apisada Jiso, Siriporn Kittiwisut, Ruttanaporn Chantakul, Supreeya Yuenyongsawad, Sumaitt Putchakarn, Till F. Schäberle, Prapapan Temkitthaworn, Kornkanok Ingkaninan, Kulathida Chaithirayanon, Anuchit Plubrukarn Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper. Journal of Natural Products. Vol.83, No.2 (2020), 532-536. doi:10.1021/acs.jnatprod.9b00886 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/53582
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Title
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
Abstract
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride.