Publication:
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper

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dc.contributor.authorApisada Jisoen_US
dc.contributor.authorSiriporn Kittiwisuten_US
dc.contributor.authorRuttanaporn Chantakulen_US
dc.contributor.authorSupreeya Yuenyongsawaden_US
dc.contributor.authorSumaitt Putchakarnen_US
dc.contributor.authorTill F. Schäberleen_US
dc.contributor.authorPrapapan Temkitthawornen_US
dc.contributor.authorKornkanok Ingkaninanen_US
dc.contributor.authorKulathida Chaithirayanonen_US
dc.contributor.authorAnuchit Plubrukarnen_US
dc.contributor.otherWalailak Universityen_US
dc.contributor.otherNaresuan Universityen_US
dc.contributor.otherJustus Liebig University Giessenen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThammasat Universityen_US
dc.contributor.otherBurapha Universityen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.contributor.otherFraunhofer Institute for Molecular Biology and Applied Ecology IMEen_US
dc.date.accessioned2020-03-26T04:30:57Z
dc.date.available2020-03-26T04:30:57Z
dc.date.issued2020-02-28en_US
dc.description.abstractCopyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride.en_US
dc.identifier.citationJournal of Natural Products. Vol.83, No.2 (2020), 532-536en_US
dc.identifier.doi10.1021/acs.jnatprod.9b00886en_US
dc.identifier.issn15206025en_US
dc.identifier.issn01633864en_US
dc.identifier.other2-s2.0-85079751529en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/53582
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079751529&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleQuintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esperen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079751529&origin=inwarden_US

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