Publication: Vasorelaxant and antioxidant activities of spilanthes acmella Murr
Issued Date
2008-12-01
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ISSN
14220067
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2-s2.0-58149229380
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.9, No.12 (2008), 2724-2744
Suggested Citation
Orapin Wongsawatkul, Supaluk Prachayasittikul, Chartchalerm Isarankura-Na-Ayudhya, Jutamaad Satayavivad, Somsak Ruchirawat, Virapong Prachayasittikul Vasorelaxant and antioxidant activities of spilanthes acmella Murr. International Journal of Molecular Sciences. Vol.9, No.12 (2008), 2724-2744. doi:10.3390/ijms9122724 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18821
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Title
Vasorelaxant and antioxidant activities of spilanthes acmella Murr
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Abstract
This study reports the effect of Spilanthes acmella Murr. extracts on phenylephrine-induced contraction of rat thoracic aorta as well as their antioxidant activity. Results show that the extracts exert maximal vasorelaxations in a dose-dependent manner, but their effects are less than acetylcholine-induced nitric oxide (NO) vasorelaxation. Significant reduction of vasorelaxations is observed in both N G-nitro-L-arginine methyl ester (L-NAME) and indomethacin (INDO). In the presence of L-NAME plus INDO, synergistic effects are observed, leading to loss of vasorelaxation of both acetylcholine and the extracts. Similarly, the vasorelaxations of the extracts are completely abolished upon the removal of endothelial cells. This demonstrates that the extracts exhibit vasorelaxation via partially endothelium-induced NO and prostacyclin in a dose-dependent manner. Significantly, the ethyl acetate extract exerts immediate vasorelaxation (ED 50 76.1 ng/mL) and is the most potent antioxidant (DPPH assay). The chloroform extract shows the highest vasorelaxation and antioxidation (SOD assay). These reveal a potential source of vasodilators and antioxidants. © 2008.