Publication:
Vasorelaxant and antioxidant activities of spilanthes acmella Murr

dc.contributor.authorOrapin Wongsawatkulen_US
dc.contributor.authorSupaluk Prachayasittikulen_US
dc.contributor.authorChartchalerm Isarankura-Na-Ayudhyaen_US
dc.contributor.authorJutamaad Satayavivaden_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorVirapong Prachayasittikulen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.date.accessioned2018-07-12T02:16:18Z
dc.date.available2018-07-12T02:16:18Z
dc.date.issued2008-12-01en_US
dc.description.abstractThis study reports the effect of Spilanthes acmella Murr. extracts on phenylephrine-induced contraction of rat thoracic aorta as well as their antioxidant activity. Results show that the extracts exert maximal vasorelaxations in a dose-dependent manner, but their effects are less than acetylcholine-induced nitric oxide (NO) vasorelaxation. Significant reduction of vasorelaxations is observed in both N G-nitro-L-arginine methyl ester (L-NAME) and indomethacin (INDO). In the presence of L-NAME plus INDO, synergistic effects are observed, leading to loss of vasorelaxation of both acetylcholine and the extracts. Similarly, the vasorelaxations of the extracts are completely abolished upon the removal of endothelial cells. This demonstrates that the extracts exhibit vasorelaxation via partially endothelium-induced NO and prostacyclin in a dose-dependent manner. Significantly, the ethyl acetate extract exerts immediate vasorelaxation (ED 50 76.1 ng/mL) and is the most potent antioxidant (DPPH assay). The chloroform extract shows the highest vasorelaxation and antioxidation (SOD assay). These reveal a potential source of vasodilators and antioxidants. © 2008.en_US
dc.identifier.citationInternational Journal of Molecular Sciences. Vol.9, No.12 (2008), 2724-2744en_US
dc.identifier.doi10.3390/ijms9122724en_US
dc.identifier.issn14220067en_US
dc.identifier.other2-s2.0-58149229380en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/18821
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149229380&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.subjectComputer Scienceen_US
dc.titleVasorelaxant and antioxidant activities of spilanthes acmella Murren_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149229380&origin=inwarden_US

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