Beta-blocker and its neuropsychiatric effects

Abstract

© 2020, Faculty of Pharmaceutical Sciences, Chulalongkorn University. All rights reserved. Norepinephrine from locus coeruleus plays roles in memory processes and behavioral controls. Locus coeruleus change is found in the primary neurodegenerative disease. The disruption of this central adrenergic pathway could contribute to neuropsychiatric symptoms. β-blockers which are indicated in many conditions both cardiovascular and non-cardiovascular diseases directly interrupt the adrenergic pathway. Their peripheral effects are well understood, but the neuropsychiatric effects are still questionable. The previous evidence postulated that the medication may cause behavioral impairment. This review focused on neuropsychiatric effects which were related to β-blockers and their underlying mechanisms. These neuropharmacologic properties should be necessary for health-care personnel to be aware of the side effects and closely take care of the patients who taking β-blockers.