Publication: Enhancing effects of Thai edible plants on 2-amino-3,8- dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay
Issued Date
2000-10-01
Resource Type
ISSN
03043835
Other identifier(s)
2-s2.0-0034308146
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Mahidol University
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SCOPUS
Bibliographic Citation
Cancer Letters. Vol.158, No.2 (2000), 195-201
Suggested Citation
Danai Tiwawech, Masao Hirose, Mitsuru Futakuchi, Cui Lin, Witaya Thamavit, Nobuyuki Ito, Tomoyuki Shirai Enhancing effects of Thai edible plants on 2-amino-3,8- dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay. Cancer Letters. Vol.158, No.2 (2000), 195-201. doi:10.1016/S0304-3835(00)00530-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25855
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Title
Enhancing effects of Thai edible plants on 2-amino-3,8- dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay
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Abstract
Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flavors or condiments in various Thai food dishes. They are known to exert strong anti-promoting activity in a test of tumor promoter-induced Epstein- Barr virus (EBV) activation. In the present study their effects on hepatocarcinogenesis were investigated in a medium-term bioassay using F344 male rats. C. hystrix significantly enhanced 2-amino-3,8-dimethylimidazo(4,5- f)quinoxaline-associated preneoplastic liver cell focus development while B. pandurata and L. galanga had borderline effects. The results suggest that C. hystrix as well as B. pandurata and L. galanga may contain agents augmenting the hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline. (C) 2000 Elsevier Science Ireland Ltd.