Publication: Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine
Issued Date
2002-03-19
Resource Type
ISSN
13835769
Other identifier(s)
2-s2.0-0036188966
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology International. Vol.51, No.1 (2002), 99-103
Suggested Citation
N. Sriwilaijareon, S. Petmitr, A. Mutirangura, M. Ponglikitmongkol, P. Wilairat Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitology International. Vol.51, No.1 (2002), 99-103. doi:10.1016/S1383-5769(01)00092-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20216
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Title
Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine
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Abstract
Telomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30-300 μM, indicating that P. falciparum telomerase might be a potential target for future malaria chemotherapy. © 2002 Elsevier Science Ireland Ltd. All rights reserved.