Publication:
Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine

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dc.contributor.authorN. Sriwilaijareonen_US
dc.contributor.authorS. Petmitren_US
dc.contributor.authorA. Mutiranguraen_US
dc.contributor.authorM. Ponglikitmongkolen_US
dc.contributor.authorP. Wilairaten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.date.accessioned2018-07-24T03:01:06Z
dc.date.available2018-07-24T03:01:06Z
dc.date.issued2002-03-19en_US
dc.description.abstractTelomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30-300 μM, indicating that P. falciparum telomerase might be a potential target for future malaria chemotherapy. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.citationParasitology International. Vol.51, No.1 (2002), 99-103en_US
dc.identifier.doi10.1016/S1383-5769(01)00092-7en_US
dc.identifier.issn13835769en_US
dc.identifier.other2-s2.0-0036188966en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/20216
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036188966&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleStage specificity of Plasmodium falciparum telomerase and its inhibition by berberineen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036188966&origin=inwarden_US

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