Publication: Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release
Issued Date
2014-01-01
Resource Type
ISSN
10960341
00426822
00426822
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2-s2.0-84904874174
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Mahidol University
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SCOPUS
Bibliographic Citation
Virology. Vol.464-465, No.1 (2014), 111-117
Suggested Citation
Promsin Masrinoul, Orapim Puiprom, Atsushi Tanaka, Miwa Kuwahara, Panjaporn Chaichana, Kazuyoshi Ikuta, Pongrama Ramasoota, Tamaki Okabayashi Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release. Virology. Vol.464-465, No.1 (2014), 111-117. doi:10.1016/j.virol.2014.05.038 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34017
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Title
Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release
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Abstract
Chikungunya virus (CHIKV) causes an acute clinical illness characterized by sudden high fever, intense joint pain, and skin rash. Recent outbreaks of chikungunya disease in Africa and Asia are a major public health concern; however, there is currently no effective licensed vaccine or specific treatment. This study reported the development of a mouse monoclonal antibody (MAb), CK47, which recognizes domain III within the viral envelope 1 protein and inhibited the viral release process, thereby preventing the production of progeny virus. The MAb had no effect on virus entry and replication processes. Thus, CK47 may be a useful tool for studying the mechanisms underlying CHIKV release and may show potential as a therapeutic agent. © 2014 Elsevier Inc.