Publication: Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release
| dc.contributor.author | Promsin Masrinoul | en_US |
| dc.contributor.author | Orapim Puiprom | en_US |
| dc.contributor.author | Atsushi Tanaka | en_US |
| dc.contributor.author | Miwa Kuwahara | en_US |
| dc.contributor.author | Panjaporn Chaichana | en_US |
| dc.contributor.author | Kazuyoshi Ikuta | en_US |
| dc.contributor.author | Pongrama Ramasoota | en_US |
| dc.contributor.author | Tamaki Okabayashi | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Osaka University | en_US |
| dc.date.accessioned | 2018-11-09T02:23:30Z | |
| dc.date.available | 2018-11-09T02:23:30Z | |
| dc.date.issued | 2014-01-01 | en_US |
| dc.description.abstract | Chikungunya virus (CHIKV) causes an acute clinical illness characterized by sudden high fever, intense joint pain, and skin rash. Recent outbreaks of chikungunya disease in Africa and Asia are a major public health concern; however, there is currently no effective licensed vaccine or specific treatment. This study reported the development of a mouse monoclonal antibody (MAb), CK47, which recognizes domain III within the viral envelope 1 protein and inhibited the viral release process, thereby preventing the production of progeny virus. The MAb had no effect on virus entry and replication processes. Thus, CK47 may be a useful tool for studying the mechanisms underlying CHIKV release and may show potential as a therapeutic agent. © 2014 Elsevier Inc. | en_US |
| dc.identifier.citation | Virology. Vol.464-465, No.1 (2014), 111-117 | en_US |
| dc.identifier.doi | 10.1016/j.virol.2014.05.038 | en_US |
| dc.identifier.issn | 10960341 | en_US |
| dc.identifier.issn | 00426822 | en_US |
| dc.identifier.other | 2-s2.0-84904874174 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/34017 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904874174&origin=inward | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.title | Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904874174&origin=inward | en_US |