Publication: Flavans from Desmos cochinchinensis as potent aromatase inhibitors
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Issued Date
2013-12-01
Resource Type
ISSN
20402511
20402503
20402503
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2-s2.0-84888142695
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Mahidol University
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SCOPUS
Bibliographic Citation
MedChemComm. Vol.4, No.12 (2013), 1590-1596
Suggested Citation
Vilailak Prachyawarakorn, Suwannee Sangpetsiripan, Panida Surawatanawong, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Flavans from Desmos cochinchinensis as potent aromatase inhibitors. MedChemComm. Vol.4, No.12 (2013), 1590-1596. doi:10.1039/c3md00166k Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31151
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Title
Flavans from Desmos cochinchinensis as potent aromatase inhibitors
Abstract
Flavans from the roots of Desmos cochinchinensis exhibited potent aromatase inhibitory activity at nanomolar levels, and could be leads for the development of anti-aromatase drugs. In addition, these aromatase inhibitors did not show pronounced cytotoxic activity. Flavans exert their inhibitory activity through binding, as revealed by molecular docking studies, with aromatase at Arg115, Met374, and Leu477; the C-7 hydroxyl (or methoxyl) forms hydrogen bonds with Met374 and Arg115 of aromatase. © 2013 The Royal Society of Chemistry.