Publication: Flavans from Desmos cochinchinensis as potent aromatase inhibitors
| dc.contributor.author | Vilailak Prachyawarakorn | en_US |
| dc.contributor.author | Suwannee Sangpetsiripan | en_US |
| dc.contributor.author | Panida Surawatanawong | en_US |
| dc.contributor.author | Chulabhorn Mahidol | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulabhorn Graduate Institute | en_US |
| dc.contributor.other | South Carolina Commission on Higher Education | en_US |
| dc.date.accessioned | 2018-10-19T04:33:44Z | |
| dc.date.available | 2018-10-19T04:33:44Z | |
| dc.date.issued | 2013-12-01 | en_US |
| dc.description.abstract | Flavans from the roots of Desmos cochinchinensis exhibited potent aromatase inhibitory activity at nanomolar levels, and could be leads for the development of anti-aromatase drugs. In addition, these aromatase inhibitors did not show pronounced cytotoxic activity. Flavans exert their inhibitory activity through binding, as revealed by molecular docking studies, with aromatase at Arg115, Met374, and Leu477; the C-7 hydroxyl (or methoxyl) forms hydrogen bonds with Met374 and Arg115 of aromatase. © 2013 The Royal Society of Chemistry. | en_US |
| dc.identifier.citation | MedChemComm. Vol.4, No.12 (2013), 1590-1596 | en_US |
| dc.identifier.doi | 10.1039/c3md00166k | en_US |
| dc.identifier.issn | 20402511 | en_US |
| dc.identifier.issn | 20402503 | en_US |
| dc.identifier.other | 2-s2.0-84888142695 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/31151 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84888142695&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Flavans from Desmos cochinchinensis as potent aromatase inhibitors | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84888142695&origin=inward | en_US |