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Purification and characterization of anti-HIV-1 protein from Canna indica L. leaves

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dc.contributor.authorApanchanid Thepouypornen_US
dc.contributor.authorChalobon Yoosooken_US
dc.contributor.authorWongsatit Chuakulen_US
dc.contributor.authorKrit Thirapanmetheeen_US
dc.contributor.authorChanita Napaswaden_US
dc.contributor.authorChanpen Wiwaten_US
dc.contributor.otherDepartment of Pharmaceutical Scienceen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-06-11T05:01:31Z
dc.date.available2018-06-11T05:01:31Z
dc.date.issued2012-11-05en_US
dc.description.abstractA novel 10 kDa protein with anti-HIV-1 reverse transcriptase (RT) inhibitory activity was isolated from leaves of Canna indica L. using a combination of native-PAGE and ammonium sulfate precipitation. HIV-1 and RT inhibitory activity was measured using a syncytium forming ΔTat/Rev MC99 virus in Tat/Rev transfected 1A2 cell line and ELISA technique, respectively. Edman N-terminal and internal amino acid sequence (using LC-MS-MS) determination revealed the 10 kDa Canna indica L. leaf protein as a putative plastocyanin. This is the first report of a plant plastocyanin with HIV-1 RT inhibitory property.en_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.43, No.5 (2012), 1153-1159en_US
dc.identifier.issn01251562en_US
dc.identifier.other2-s2.0-84868144577en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/14527
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868144577&origin=inwarden_US
dc.subjectMedicineen_US
dc.titlePurification and characterization of anti-HIV-1 protein from Canna indica L. leavesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868144577&origin=inwarden_US

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