Publication: New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana
Issued Date
2018-01-01
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ISSN
20462069
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2-s2.0-85047479838
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Mahidol University
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SCOPUS
Bibliographic Citation
RSC Advances. Vol.8, No.33 (2018), 18204-18215
Suggested Citation
Natthakaln Lomchoey, Panomwan Panseeta, Pornthip Boonsri, Nuttapon Apiratikul, Samran Prabpai, Palangpon Kongsaeree, Sunit Suksamrarn New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana. RSC Advances. Vol.8, No.33 (2018), 18204-18215. doi:10.1039/c7ra13050c Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45453
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Title
New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana
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Abstract
© The Royal Society of Chemistry 2018. Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM.