Publication: New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana
| dc.contributor.author | Natthakaln Lomchoey | en_US |
| dc.contributor.author | Panomwan Panseeta | en_US |
| dc.contributor.author | Pornthip Boonsri | en_US |
| dc.contributor.author | Nuttapon Apiratikul | en_US |
| dc.contributor.author | Samran Prabpai | en_US |
| dc.contributor.author | Palangpon Kongsaeree | en_US |
| dc.contributor.author | Sunit Suksamrarn | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulachomklao Royal Military Academy | en_US |
| dc.contributor.other | Srinakharinwirot University | en_US |
| dc.date.accessioned | 2019-08-23T10:46:42Z | |
| dc.date.available | 2019-08-23T10:46:42Z | |
| dc.date.issued | 2018-01-01 | en_US |
| dc.description.abstract | © The Royal Society of Chemistry 2018. Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM. | en_US |
| dc.identifier.citation | RSC Advances. Vol.8, No.33 (2018), 18204-18215 | en_US |
| dc.identifier.doi | 10.1039/c7ra13050c | en_US |
| dc.identifier.issn | 20462069 | en_US |
| dc.identifier.other | 2-s2.0-85047479838 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/45453 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047479838&origin=inward | en_US |
| dc.subject | Chemical Engineering | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047479838&origin=inward | en_US |