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Structural evidence of glycoprotein assembly in cellular membrane compartments prior to alphavirus budding

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dc.contributor.authorPan Soonsawaden_US
dc.contributor.authorLi Xingen_US
dc.contributor.authorEmerson Millaen_US
dc.contributor.authorJuan M. Espinozaen_US
dc.contributor.authorMasaaki Kawanoen_US
dc.contributor.authorMichael Markoen_US
dc.contributor.authorChyongere Hsiehen_US
dc.contributor.authorHiromitsu Furukawaen_US
dc.contributor.authorMasahiro Kawasakien_US
dc.contributor.authorWattana Weerachatyanukulen_US
dc.contributor.authorRanjana Srivastavaen_US
dc.contributor.authorSusan W. Barnetten_US
dc.contributor.authorIndresh K. Srivastavaen_US
dc.contributor.authorR. Holland Chengen_US
dc.contributor.otherUniversity of California, Davisen_US
dc.contributor.otherWadsworth Center for Laboratories and Researchen_US
dc.contributor.otherJapan Electron Optics Laboratory System and Technology Co.en_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNovartis Vaccines and Diagnostics, Inc.en_US
dc.date.accessioned2018-09-24T08:40:19Z
dc.date.available2018-09-24T08:40:19Z
dc.date.issued2010-01-01en_US
dc.description.abstractMembrane glycoproteins of alphavirus play a critical role in the assembly and budding of progeny virions. However, knowledge regarding transport of viral glycoproteins to the plasma membrane is obscure. In this study, we investigated the role of cytopathic vacuole type II (CPV-II) through in situ electron tomography of alphavirus-infected cells. The results revealed that CPV-II contains viral glycoproteins arranged in helical tubular arrays resembling the basic organization of glycoprotein trimers on the envelope of the mature virions. The location of CPV-II adjacent to the site of viral budding suggests a model for the transport of structural components to the site of budding. Thus, the structural characteristics of CPV-II can be used in evaluating the design of a packaging cell line for replicon production. Copyright © 2010, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.citationJournal of Virology. Vol.84, No.21 (2010), 11145-11151en_US
dc.identifier.doi10.1128/JVI.00036-10en_US
dc.identifier.issn10985514en_US
dc.identifier.issn0022538Xen_US
dc.identifier.other2-s2.0-77957957373en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/28557
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957957373&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleStructural evidence of glycoprotein assembly in cellular membrane compartments prior to alphavirus buddingen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957957373&origin=inwarden_US

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