Publication: Association analysis of CYP2C9∗3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children
1
Issued Date
2015-01-01
Resource Type
ISSN
1435232X
14345161
14345161
Other identifier(s)
2-s2.0-84940054264
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Human Genetics. Vol.60, No.8 (2015), 413-417
Suggested Citation
Supharat Suvichapanich, Jiraphun Jittikoon, Nuanjun Wichukchinda, Wasu Kamchaisatian, Anannit Visudtibhan, Suwat Benjapopitak, Somjai Nakornchai, Wiparat Manuyakorn, Surakameth Mahasirimongkol Association analysis of CYP2C9∗3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children. Journal of Human Genetics. Vol.60, No.8 (2015), 413-417. doi:10.1038/jhg.2015.47 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35515
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Association analysis of CYP2C9∗3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children
Other Contributor(s)
Abstract
© 2015 The Japan Society of Human Genetics. CYP2C9 is the key enzyme in aromatic antiepileptic drugs (AEDs) metabolism. CYP2C9∗3 is a loss of function polymorphism. This study was designed to investigate genetic association between CYP2C9∗3 and aromatic AED-induced severe cutaneous adverse reactions (SCARs) in Thai children. The 37 aromatic AED-induced SCARs patients (20 phenobarbital and 17 phenytoin) and 35 tolerances (19 phenobarbital and 16 phenytoin) were enrolled. CYP2C9∗3 was genotyped by allele-specific PCRs. The association between CYP2C9∗3 with phenytoin-induced SCARs and phenobarbital-induced SCARs were analyzed in comparison with tolerances and healthy samples. Significant association between phenytoin-induced SCARs and CYP2C9∗3 was discovered (odds ratio=14.52; 95% confidence interval (CI)=1.18-∞, P-value=0.044). CYP2C9∗3 was not associated with phenobarbital-induced SCARs. This study is the first report of CYP2C9∗3 association to phenytoin-induced SCARs in Thai epileptic children. The CYP2C9∗3 is a reasonable predictive genetic marker to anticipate SCARs from phenytoin.