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Association analysis of CYP2C9∗3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children

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dc.contributor.authorSupharat Suvichapanichen_US
dc.contributor.authorJiraphun Jittikoonen_US
dc.contributor.authorNuanjun Wichukchindaen_US
dc.contributor.authorWasu Kamchaisatianen_US
dc.contributor.authorAnannit Visudtibhanen_US
dc.contributor.authorSuwat Benjapopitaken_US
dc.contributor.authorSomjai Nakornchaien_US
dc.contributor.authorWiparat Manuyakornen_US
dc.contributor.authorSurakameth Mahasirimongkolen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherDepartment of Medical Scienceen_US
dc.date.accessioned2018-11-23T09:46:33Z
dc.date.available2018-11-23T09:46:33Z
dc.date.issued2015-01-01en_US
dc.description.abstract© 2015 The Japan Society of Human Genetics. CYP2C9 is the key enzyme in aromatic antiepileptic drugs (AEDs) metabolism. CYP2C9∗3 is a loss of function polymorphism. This study was designed to investigate genetic association between CYP2C9∗3 and aromatic AED-induced severe cutaneous adverse reactions (SCARs) in Thai children. The 37 aromatic AED-induced SCARs patients (20 phenobarbital and 17 phenytoin) and 35 tolerances (19 phenobarbital and 16 phenytoin) were enrolled. CYP2C9∗3 was genotyped by allele-specific PCRs. The association between CYP2C9∗3 with phenytoin-induced SCARs and phenobarbital-induced SCARs were analyzed in comparison with tolerances and healthy samples. Significant association between phenytoin-induced SCARs and CYP2C9∗3 was discovered (odds ratio=14.52; 95% confidence interval (CI)=1.18-∞, P-value=0.044). CYP2C9∗3 was not associated with phenobarbital-induced SCARs. This study is the first report of CYP2C9∗3 association to phenytoin-induced SCARs in Thai epileptic children. The CYP2C9∗3 is a reasonable predictive genetic marker to anticipate SCARs from phenytoin.en_US
dc.identifier.citationJournal of Human Genetics. Vol.60, No.8 (2015), 413-417en_US
dc.identifier.doi10.1038/jhg.2015.47en_US
dc.identifier.issn1435232Xen_US
dc.identifier.issn14345161en_US
dc.identifier.other2-s2.0-84940054264en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/35515
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940054264&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleAssociation analysis of CYP2C9∗3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy childrenen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940054264&origin=inwarden_US

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