Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.
Färnert A, Ursing J, Tolfvenstam T, Rono J, Karlsson L, Sparrelid E, et al. Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania. Malar J. 2012 May 25;11:176.
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Färnert, Anna, Ursing, Johan, Tolfvenstam, Thomas, Rono, Josea, Karlsson, Lillemor, Sparrelid, Elda, Lindegårdh, Niklas Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.. Färnert A, Ursing J, Tolfvenstam T, Rono J, Karlsson L, Sparrelid E, et al. Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania. Malar J. 2012 May 25;11:176.. doi:10.1186/1475-2875-11-176. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/666
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Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.
Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum
malaria in many countries. This report describes a treatment failure despite
adequate drug concentrations in a traveller returning from sub-Saharan Africa.
Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential
sub-optimal effect of artemether-lumefantrine highlights the need to follow
non-immune individuals the weeks after treatment.
