Publication: Genomic characterization of carbapenemase-producing klebsiella pneumoniae with chromosomally carried bla <inf>NDM-1</inf>
Issued Date
2018-12-01
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ISSN
10986596
00664804
00664804
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2-s2.0-85057185517
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.62, No.12 (2018)
Suggested Citation
Noriko Sakamoto, Yukihiro Akeda, Yo Sugawara, Dan Takeuchi, Daisuke Motooka, Norihisa Yamamoto, Warawut Laolerd, Pitak Santanirand, Shigeyuki Hamada Genomic characterization of carbapenemase-producing klebsiella pneumoniae with chromosomally carried bla <inf>NDM-1</inf>. Antimicrobial Agents and Chemotherapy. Vol.62, No.12 (2018). doi:10.1128/AAC.01520-18 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46157
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Title
Genomic characterization of carbapenemase-producing klebsiella pneumoniae with chromosomally carried bla <inf>NDM-1</inf>
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Abstract
© 2018 American Society for Microbiology. All Rights Reserved. We report here Klebsiella pneumoniae strains carrying chromosomal bla NDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing bla NDM-1 , which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of bla NDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.