Publication: Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
Issued Date
2009-11-01
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ISSN
14203049
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2-s2.0-73349142009
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.14, No.11 (2009), 4414-4424
Suggested Citation
Supaluk Prachayasittikul, Patumporn Manam, Maneekarn Chinworrungsee, Chartchalerm Isarankura-Na-ayudhya, Somsak Ruchirawat, Virapong Prachayasittikul Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.. Molecules. Vol.14, No.11 (2009), 4414-4424. doi:10.3390/molecules14114414 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27392
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Title
Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
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Abstract
This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.