Publication: Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
| dc.contributor.author | Supaluk Prachayasittikul | en_US |
| dc.contributor.author | Patumporn Manam | en_US |
| dc.contributor.author | Maneekarn Chinworrungsee | en_US |
| dc.contributor.author | Chartchalerm Isarankura-Na-ayudhya | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Virapong Prachayasittikul | en_US |
| dc.contributor.other | Srinakharinwirot University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.date.accessioned | 2018-09-13T06:30:20Z | |
| dc.date.available | 2018-09-13T06:30:20Z | |
| dc.date.issued | 2009-11-01 | en_US |
| dc.description.abstract | This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications. | en_US |
| dc.identifier.citation | Molecules. Vol.14, No.11 (2009), 4414-4424 | en_US |
| dc.identifier.doi | 10.3390/molecules14114414 | en_US |
| dc.identifier.issn | 14203049 | en_US |
| dc.identifier.other | 2-s2.0-73349142009 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/27392 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73349142009&origin=inward | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep. | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73349142009&origin=inward | en_US |