Publication: HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
Issued Date
2015-10-01
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ISSN
1546170X
10788956
10788956
DOI
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2-s2.0-84943663211
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Medicine. Vol.21, No.10 (2015), 1139-1141
Suggested Citation
Holly Janes, Joshua T. Herbeck, Sodsai Tovanabutra, Rasmi Thomas, Nicole Frahm, Ann Duerr, John Hural, Lawrence Corey, Steve G. Self, Susan P. Buchbinder, M. Juliana McElrath, Robert J. O'Connell, Robert M. Paris, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttihum, Jaranit Kaewkungwal, Merlin L. Robb, Nelson L. Michael, James I. Mullins, Jerome H. Kim, Peter B. Gilbert, Morgane Rolland HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders. Nature Medicine. Vol.21, No.10 (2015), 1139-1141. doi:10.1038/nm.3932 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35376
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Title
HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
Author(s)
Holly Janes
Joshua T. Herbeck
Sodsai Tovanabutra
Rasmi Thomas
Nicole Frahm
Ann Duerr
John Hural
Lawrence Corey
Steve G. Self
Susan P. Buchbinder
M. Juliana McElrath
Robert J. O'Connell
Robert M. Paris
Supachai Rerks-Ngarm
Sorachai Nitayaphan
Punnee Pitisuttihum
Jaranit Kaewkungwal
Merlin L. Robb
Nelson L. Michael
James I. Mullins
Jerome H. Kim
Peter B. Gilbert
Morgane Rolland
Joshua T. Herbeck
Sodsai Tovanabutra
Rasmi Thomas
Nicole Frahm
Ann Duerr
John Hural
Lawrence Corey
Steve G. Self
Susan P. Buchbinder
M. Juliana McElrath
Robert J. O'Connell
Robert M. Paris
Supachai Rerks-Ngarm
Sorachai Nitayaphan
Punnee Pitisuttihum
Jaranit Kaewkungwal
Merlin L. Robb
Nelson L. Michael
James I. Mullins
Jerome H. Kim
Peter B. Gilbert
Morgane Rolland
Abstract
© 2015 Nature America, Inc. All rights reserved. Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found - in two different cohorts - that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.